Chávez B, Espinosa-Cantellano M, Cedillo Rivera R, Ramírez A, Martínez-Palomo A
Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, México, DF, México.
Arch Med Res. 1992;23(2):63-7.
Albendazole, a benzimidazole carbamate commonly used for the treatment and control of intestinal helminthic infections, is also useful for the treatment of giardiasis. Therefore, it is of interest to determine whether the drug has activity against other intestinal protozoa, such as E. histolytica. The present results demonstrate that albendazole inhibits the growth of E. histolytica trophozoites in axenic cultures and induces fine structural changes such as polyribosome aggregation and loss of cytoplasmic vacuoles at concentrations up to 10 micrograms/ml. The viability of E. histolytica trophozoites was not affected by the drug. In contrast, lower concentrations of albendazole showed dramatic effects on G. lamblia trophozoites. These included loss of adhesiveness, striking modifications of the overall morphology of giardias, disassembly of the ventral disk, and loss of viability after prolonged treatment. The results provide further evidence on the potent antigiardial activity of albendazole and indicate that, at the concentrations used, the drug has no antiamebic activity.
阿苯达唑是一种常用于治疗和控制肠道蠕虫感染的苯并咪唑氨基甲酸酯，对贾第虫病的治疗也很有用。因此，确定该药物对其他肠道原生动物（如溶组织内阿米巴）是否有活性很有意义。目前的结果表明，阿苯达唑在无菌培养中可抑制溶组织内阿米巴滋养体的生长，并在浓度高达10微克/毫升时诱导细微的结构变化，如多核糖体聚集和细胞质空泡的丧失。溶组织内阿米巴滋养体的活力不受该药物影响。相比之下，较低浓度的阿苯达唑对蓝氏贾第鞭毛虫滋养体有显著影响。这些影响包括黏附性丧失、贾第虫整体形态的显著改变、腹盘解体以及长时间处理后活力丧失。结果为阿苯达唑强大的抗贾第虫活性提供了进一步证据，并表明在所使用的浓度下，该药物没有抗阿米巴活性。
