González-Garza M T, Matlin S A, Mata-Cárdenas B D, Said-Fernández S
Unidad de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social, Monterrey, NL.
Arch Med Res. 1992;23(2):69-70.
Gossypol has an in vitro antiamebic effect, which is 11,39, and 980 times more potent than emetime, metronidazole and diiodohydroxyquinolein, respectively, on five Entamoeba histolytica axenic strains. The trophozoite NADP-dependent malic enzyme and alcohol dehydrogenase are inhibited by (+/-)-gossypol, in a noncompetitive manner with respect to the substrate. From the (-)- and (+)- enantiomers, which integrate the natural gossypol mixture, the first one is three and four times more active in inhibiting both the amebic culture growth and the mentioned oxidoreductases, respectively. The above results justify the analysis of gossypol as an antiamebic drug in experimentally infected animals.
棉酚具有体外抗阿米巴作用，在五种溶组织内阿米巴纯培养菌株上，其效力分别比依米丁、甲硝唑和双碘喹啉强11倍、39倍和980倍。（±）-棉酚以非竞争性方式抑制滋养体的NADP依赖性苹果酸酶和乙醇脱氢酶。天然棉酚混合物中的（-）-和（+）-对映体，前者在抑制阿米巴培养生长和上述氧化还原酶方面的活性分别高3倍和4倍。上述结果证明了在实验感染动物中对棉酚作为抗阿米巴药物进行分析的合理性。
