González-Garza M T, Matlin S A, Mata-Cárdenas B D, Said-Fernández S
Unidad de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social, Monterrey, Nuevo Leon.
J Pharm Pharmacol. 1993 Feb;45(2):144-5. doi: 10.1111/j.2042-7158.1993.tb03701.x.
The in-vitro anti-amoebic effects of (+/-)-, (+)-, (-)-gossypol and emetine were tested against axenic trophozoites from five Entamoeba histolytica strains. The (-)-isomer was more active than the racemate and the (+)-isomer. These results indicate that the gossypol anti-amoebic activity is mainly due to its content of (-)-gossypol in all strains tested.
测试了（±）-、（+）-、（-）-棉酚和吐根碱对来自五种溶组织内阿米巴菌株的无菌滋养体的体外抗阿米巴作用。（-）-异构体比外消旋体和（+）-异构体更具活性。这些结果表明，在所测试的所有菌株中，棉酚的抗阿米巴活性主要归因于其（-）-棉酚的含量。
