Gorecki D K, Hindmarsh K W, Hall C A, Mayers D J, Sankaran K
College of Pharmacy, University of Saskatchewan, Saskatoon, Canada.
J Chromatogr. 1990 Jun 29;528(2):333-41. doi: 10.1016/s0378-4347(00)82392-0.
A simple, rapid and sensitive electron-capture gas chromatographic method has been developed for the simultaneous determination of chloral hydrate, trichloroethanol and trichloroacetic acid in biological fluids. The described method is applicable to single-dose pharmacokinetic studies of chloral hydrate in the adult. The method also meets the important requirement of using very small sample volumes and is sufficiently sensitive and reliable for disposition studies in the neonate.
已开发出一种简单、快速且灵敏的电子捕获气相色谱法，用于同时测定生物体液中的水合氯醛、三氯乙醇和三氯乙酸。所述方法适用于成人水合氯醛的单剂量药代动力学研究。该方法还满足使用极少量样本体积这一重要要求，并且对于新生儿的处置研究足够灵敏和可靠。
