SMITH C A, KAMP M, OLANSKY S, PRICE E V
Bull World Health Organ. 1956;15(6):1087-96.
Post-treatment observation of two years' duration has confirmed preliminary data which indicated that a single injection of 2.5 million units of benzathine penicillin G, in early infectious syphilis, produces results equal, if not superior, to those obtained with schedules employing 4.8 million units of procaine penicillin and aluminium monostearate.Preliminary data suggest that a single injection of 2.4 or 2.5 million units of benzathine penicillin G may be inadequate for the treatment of asymptomatic neurosyphilis.Delayed reactions do not appear to be induced by the long-sustained blood-levels following the administration of benzathine penicillin G.Repeated injections of PAM increase the risk of reaction to treatment.
为期两年的治疗后观察证实了初步数据，这些数据表明，在早期传染性梅毒中，单次注射250万单位苄星青霉素G所产生的效果即便不优于、也等同于使用480万单位普鲁卡因青霉素和单硬脂酸铝的治疗方案所取得的效果。初步数据表明，单次注射240万或250万单位苄星青霉素G可能不足以治疗无症状神经梅毒。苄星青霉素G给药后血液中长时间维持的药物水平似乎不会引发延迟反应。重复注射普鲁卡因青霉素铝会增加治疗反应的风险。
