Arenoso H J, Dall L L, Soutric J L, Martin J
Area de Desarrollo Analítico y Farmacéutico, Laboratorios Bagó, Buenos Aires, Argentina.
Medicina (B Aires). 1992;52(6):555-9.
Theophylline pharmacokinetics, administered in tablets containing 600 mg in a sustained-release hydrophilic matrix for a once daily intake, was evaluated after being administered to 6 healthy volunteers during 7 days at 8 pm. Plasmatic levels at -2, 0, 2, 3, 4, 6, 8, 10, 12, 14, 18 and 24 hours in relation with 8 pm intake, were obtained at the 7th day of administration. A plasmatic curve was obtained with a maximum concentration at 12 hours of 10.18 mcg/ml, a minimum concentration of 3.27 mcg/ml and an area under the concentration/time curve of 198.4 mcg.h/ml. These data make it evident that the tablet studied shows a release profile without excessive peaks and an average concentration at steady state within therapeutical range, and suggests its use in asthma.
对6名健康志愿者于晚上8点连续7天服用含600毫克茶碱的亲水缓释基质片后的药代动力学进行了评估。在给药第7天，获取了与晚上8点服药相关的 -2、0、2、3、4、6、8、10、12、14、18和24小时的血浆水平。获得了一条血浆曲线，12小时时的最大浓度为10.18微克/毫升，最小浓度为3.27微克/毫升，浓度/时间曲线下面积为198.4微克·小时/毫升。这些数据表明，所研究的片剂显示出无过高峰的释放曲线，且稳态时的平均浓度在治疗范围内，提示其可用于哮喘治疗。
