Casasín Edo T, Llusa Arbos M, Gómez Papi A, Closa Monasterolo R, Tarrés Roure A
Servicio de Farmacia, Hospital Juan XXIII, Tarragona.
An Esp Pediatr. 1988 Sep;29(3):220-2.
In order to defined the theophylline dose which produce effective theophylline concentrations with less number of plasmatic controls, we analyzed the theophylline pharmacokinetics of 18 boys and girls between 3-12 year olds of Tarragona, to which we administered 6 mg/kg/6 h of aminophylline by IV intermittent infusion (30 min), following by rapid-release PO aminophylline at the same dose and intervals. In steady-state we did the pharmacokinetic studies at 1 h, 4 h and 6 h after the administration of one dose. The maintenance dose obtained was administered PO as slow-release theophylline, with later controls of theophylline concentration. We found that maintenance dose of 24.1 +/- 4.7 mg/kg/day (mean +/- SD) allowed theophylline concentration between therapeutic levels in the population studied.
为了确定能以较少的血浆监测次数产生有效茶碱浓度的茶碱剂量，我们分析了塔拉戈纳18名3至12岁男孩和女孩的茶碱药代动力学。我们通过静脉间歇输注（30分钟）给予他们6毫克/千克/6小时的氨茶碱，随后以相同剂量和间隔给予速释口服氨茶碱。在稳态时，我们在一剂给药后1小时、4小时和6小时进行药代动力学研究。获得的维持剂量以缓释茶碱口服给药，随后监测茶碱浓度。我们发现，24.1±4.7毫克/千克/天（平均值±标准差）的维持剂量可使所研究人群的茶碱浓度处于治疗水平之间。
