Casanova E R, Cabrera M E, Klaasen R, Tapia P, Yáñez V
Servicio de Medicina Hospital Naval de Talcahuano, Sección Hematología Salvador Santiago, Chile.
Rev Med Chil. 1992 Sep;120(9):1033-6.
A patient with acute mixed myelocytic and lymphocytic leukemia is reported. The patient showed two populations of malignant myeloid and lymphoid cells with predominance of myeloid lineage. According to the present knowledge, it is hypothesized that its origin is at a pluripotent transformed stem cell which has the capability of differentiating through myeloid and lymphoid lineages. Its maturation is arrested at certain level, thus raising two monoclonal populations simultaneously in the same patient. The treatment should be combined with drugs used in acute myeloblastic and lymphoblastic leukemia. The response to chemotherapy is generally poor.
报道了一名患有急性混合性髓细胞和淋巴细胞白血病的患者。该患者显示出两种恶性髓系和淋巴系细胞群，以髓系为主。根据目前的知识，推测其起源于一个多能转化干细胞，该干细胞具有通过髓系和淋巴系分化的能力。其成熟在一定水平上停滞，从而在同一患者中同时产生两个单克隆细胞群。治疗应结合用于急性髓细胞白血病和淋巴细胞白血病的药物。化疗反应通常较差。
