Iacopino P, Comis M, Callea V, Martino B, Latella C, Abenavoli M R, Neri A
Haematologia (Budap). 1986;19(2):117-20.
Based on conventional and immunological cell markers the great majority of acute leukemias can be classified as of lymphoid or myeloid origin. However, in some instances, leukemic cells with both lymphoid and myeloid features are found. For these cases the term of hybrid leukemia has been suggested; moreover, it has been shown that dual markers can be expressed by the same cell (biphenotypic leukemia) or myeloid and lymphoid cell populations coexist (biclonal leukemia). The accurate typing of acute leukemia is crucial in order to entail treatment and predict survival; therefore, the identification of acute hybrid leukemias may be important not only in terms of biological significance but also of management and outcome. We report here two further cases of acute hybrid leukemia with poor response to chemotherapy and very short survival.
基于传统的和免疫细胞标志物，绝大多数急性白血病可被分类为淋巴系或髓系起源。然而，在某些情况下，会发现具有淋巴系和髓系特征的白血病细胞。对于这些病例，有人提出了混合白血病这一术语；此外，已表明双标志物可由同一细胞表达（双表型白血病）或髓系和淋巴系细胞群共存（双克隆白血病）。急性白血病的准确分型对于确定治疗方案和预测生存期至关重要；因此，急性混合白血病的识别不仅在生物学意义方面可能很重要，而且在治疗管理和预后方面也可能很重要。我们在此报告另外两例急性混合白血病病例，这两例对化疗反应不佳且生存期极短。
