Vrandecic M, Gontijo B F, Fantini F A, Gutierrez C, Silva J A, Barbosa J T, Andrade C A
Biocor Institute of Cardiology and Research Center, Belo Horizonte, Brasil.
J Heart Valve Dis. 1992 Nov;1(2):254-9; discussion 253.
The use of a totally anatomical mitral valve heterograft as a mitral valve substitute has been proven to be technically feasible. A new stentless mitral porcine heart valve substitute was therefore developed to match the physiology and flow characteristics of the left ventricle and mitral valve complex, and tested in non-survival animal experiments. Having sought the approval of the Hospital Ethics Committee and the consent of each individual patient, this valve was implanted into 18 patients with diseased mitral valves. The duration of the procedure is approximately the same as for standard mitral valve replacement. The sizing of the valve and the anchoring of the sutures to the papillary muscle, although very straightforward, do require adherence to a protocol. The immediate clinical results are encouraging, although the first patient required a reoperation because of a patient/valve mismatch. All patients, including the patient reoperated, are in functional class I after four to 26 weeks of follow up. The patients will be followed by monthly clinical and Doppler echocardiographic examinations, as they have been so far, for the next 12 months, and annually thereafter.
使用完全解剖学的二尖瓣异种移植物作为二尖瓣替代物已被证明在技术上是可行的。因此，开发了一种新的无支架猪二尖瓣心脏瓣膜替代物，以匹配左心室和二尖瓣复合体的生理和血流特性，并在非存活动物实验中进行了测试。在获得医院伦理委员会的批准和每位患者的同意后，将该瓣膜植入18例二尖瓣病变患者体内。手术时间与标准二尖瓣置换术大致相同。瓣膜的尺寸确定以及缝线在乳头肌上的固定，虽然非常简单，但确实需要遵循一定的操作流程。尽管第一例患者因患者/瓣膜不匹配需要再次手术，但即时临床结果令人鼓舞。经过4至26周的随访，所有患者，包括再次手术的患者，心功能均为I级。此后，患者将像迄今为止一样，在接下来的12个月内每月进行临床和多普勒超声心动图检查，之后每年检查一次。
