Yamashita A
Department of Physiology, Primate Research Institute, Kyoto University, Aichi, Japan.
Int J Neurosci. 1992 May-Jun;64(1-4):139-51. doi: 10.3109/00207459209000540.
Distribution of cholecystokinin (CCK)-immunoreactive structures was studied in various neocortical areas of macaque monkeys during prenatal and postnatal development. The largest number of CCK-immunoreactive cells was observed at embryonic day 140, and subsequently they decreased in number until postnatal day 60. A few cells which were presumably degenerated neurons were observed during postnatal development. A higher density of CCK-immunoreactive cells was observed in the supragranular layers (layers II and III) than in the infragranular layers (layers V and VI). The number of CCK-immunoreactive cells was larger and changed more conspicuously in the association areas than in the other areas during development. In contrast, in the occipital area, the number of such cells was small and changed only a little. These findings suggest that CCK may be involved in the development and special function of each neocortical areas of the primate.
在猕猴产前和产后发育过程中，研究了胆囊收缩素（CCK）免疫反应性结构在不同新皮质区域的分布。在胚胎第140天观察到数量最多的CCK免疫反应性细胞，随后其数量减少，直至出生后第60天。在产后发育过程中观察到一些可能是退化神经元的细胞。与颗粒下层（第V层和第VI层）相比，在颗粒上层（第II层和第III层）观察到更高密度的CCK免疫反应性细胞。在发育过程中，联合区域中CCK免疫反应性细胞的数量更多，变化也比其他区域更明显。相反，在枕叶区域，此类细胞数量较少，变化也很小。这些发现表明CCK可能参与灵长类动物每个新皮质区域的发育和特殊功能。
