Eskenasy A
Morphol Embryol (Bucur). 1976 Apr-Jun;22(2):115-21.
The histopathologic investigation of 300 resected lungs, especially with carcinomatous lesions, as well as of the experimental material provided by bronchial ligature and by intratracheal injections of viscous substances, permits the demonstration of the effects of acute and chronic bronchial obstruction and of their evolution. In acute obstructions, the process is dominated by circulatory changes and in the chronic ones by lesions of large alveolocytes, by changes in the lung lipidic metabolism induced by the hypoventilation, as well as by alveolar reactions with lipospongiocytary macrophages and giant cells. In both modalities, the bronchial obstructive process evolves to lung atelectasis with organization of affected areas, exclusion of lobuli and bronchiolar alveolization. The bronchial obstruction, an important morphological expression of the aerogenic component in lung pathogenesis, appears to be a main factor in the reshuffling of damaged lung areas by cellulo-fibrillar restructuration.
对300例切除肺脏（尤其是伴有癌性病变的肺脏）进行组织病理学研究，以及对支气管结扎和气管内注射粘性物质所提供的实验材料进行研究，能够证明急性和慢性支气管阻塞的影响及其演变过程。在急性阻塞中，该过程以循环变化为主导；而在慢性阻塞中，则以大肺泡细胞的病变、通气不足引起的肺脂质代谢变化以及肺泡与脂质性海绵状巨噬细胞和巨细胞的反应为主导。在这两种情况下，支气管阻塞过程都会发展为肺不张，并伴有受累区域的机化、小叶的排除和细支气管肺泡化。支气管阻塞是肺部发病机制中空气源性成分的重要形态学表现，似乎是通过细胞纤维结构重组来重新排列受损肺区的主要因素。
