Eskenasy A
Morphol Embryol (Bucur). 1980 Jan-Mar;26(1):55-64.
Lung tissue restructuration is one of the most important components of chronic pneumopathies. Comparison of experimental and human data regarding the dynamic evolution of variously induced chronic lung processes pointed out as main mechanisms the bronchial and bronchiolar obstructions, the viral and fungal pneumonitic processes, the parenchymatous suppurative processes, the granulomatous organization of cellular reactions, the interlobular cell accumulations, the hypersensitivity reactions, and the lesions of small vessels. Mostly acting in association, these dynamic conditions determine the fibroplastic transformation of lesions, the exclusion of unventilated areas, the destruction of respiratory surfaces, the clear predominance of connective tissue structures, sometimes with ossifications; some microcavities persist within restructuring areas, sometimes delimited by alveolar or bronchiolar epithelia. The honeycomb lung is one of the evolutive possibilities of this restructuration of damaged tissues during chronic lung diseases.
肺组织重构是慢性肺部疾病最重要的组成部分之一。关于各种诱导性慢性肺部疾病动态演变的实验数据与人体数据对比表明，主要机制包括支气管和细支气管阻塞、病毒性和真菌性肺炎过程、实质性化脓过程、细胞反应的肉芽肿性组织形成、小叶间细胞聚集、超敏反应以及小血管病变。这些动态情况大多共同作用，决定了病变的纤维增生性转化、未通气区域的排除、呼吸表面的破坏、结缔组织结构的明显占优势，有时还伴有骨化；在重构区域内会持续存在一些微腔，有时由肺泡或细支气管上皮界定。蜂窝肺是慢性肺部疾病期间受损组织这种重构的一种演变可能性。
