罗红霉素和红霉素对革兰氏阳性球菌的体外抗生素后效应

In vitro postantibiotic effect of roxithromycin and erythromycin against gram-positive cocci.

作者信息

Chang J C, Hsueh P R, Young C

机构信息

Department of Medical Technology, Medical College, National Cheng-Kung University, Tainan, Taiwan, R.O.C.

出版信息

Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1992 Nov;25(4):276-84.

PMID:1342645

Abstract

A persistent suppression of bacterial growth following a brief exposure to an antibiotic (postantibiotic effect [PAE]) has been described for a variety of antibiotics and microorganisms. Data concerning PAE have not yet been demonstrated in Taiwan. In this study, the PAEs of erythromycin (EM) and roxithromycin (RXM) against 4 strains of Staphylococcus aureus, 3 of Streptococcus pyogenes and 1 of Streptococcus pneumoniae were tested. Dilution method was used for removal of drugs. Two controls, one free of drug and one in 1/1000 of the original drug concentrations were used. The results showed that the PAE lasted longer in strains of S. aureus (RXM 1.7-2.1 h; EM 1.7-2.1 h) and S. pyogenes (RXM 1.7-3.0 h; EM 1.9-2.9 h) than those in S. pneumoniae (RXM 0.6-1.6 h; EM 0.8-1.4 h). There was no difference of PAE between RXM and EM against each bacterial strain tested.

摘要

多种抗生素和微生物在短暂接触抗生素后会出现细菌生长的持续抑制（抗生素后效应[PAE]）。台湾地区尚未有关于PAE的数据报道。本研究检测了红霉素（EM）和罗红霉素（RXM）对4株金黄色葡萄球菌、3株化脓性链球菌和1株肺炎链球菌的PAE。采用稀释法去除药物。设置两个对照组，一个不含药物，另一个含1/1000原始药物浓度。结果显示，PAE在金黄色葡萄球菌（RXM 1.7 - 2.1小时；EM 1.7 - 2.1小时）和化脓性链球菌（RXM 1.7 - 3.0小时；EM 1.9 - 2.9小时）菌株中持续时间比肺炎链球菌（RXM 0.6 - 1.6小时；EM 0.8 - 1.4小时）更长。在测试的每种细菌菌株中，RXM和EM之间的PAE没有差异。