Kuenzi B, Segessenmann C, Gerber A U
Medizinische Abteilung, Regionalspital, Burgdorf, Switzerland.
J Antimicrob Chemother. 1987 Nov;20 Suppl B:39-46. doi: 10.1093/jac/20.suppl_b.39.
Recent experimental work has shown that a so-called PAE (postantibiotic effect, i.e. persistent suppression of regrowth after short exposure of bacteria to the study drug in vitro) is a feature of most current antibiotics. However, marked quantitative differences were found between different types of antibiotics and also between Gram-positive and Gram-negative organisms studied. A PAE has not yet been demonstrated for roxithromycin, a new macrolide antibiotic. Therefore, we compared the PAE of roxithromycin, erythromycin, and clindamycin against laboratory strains and clinical isolates of Staphylococcus aureus, Streptococcus pyogenes, Str. pneumoniae, and Haemophilus influenzae in vitro. Identical multiples of the MIC and identical exposure times resulted in similar PAEs for the three study drugs tested. Good correlations could be found between the area under the in-vitro concentration-vs-time curve (AUC) and PAEs. The longest PAE of 9.6 h was observed after exposure of Str. pneumoniae to 1.9 mg/l of roxithromycin for 6 h.
最近的实验研究表明，所谓的PAE（抗生素后效应，即在体外将细菌短暂暴露于受试药物后对其再生长的持续抑制作用）是大多数现有抗生素的一个特性。然而，在不同类型的抗生素之间以及在所研究的革兰氏阳性菌和革兰氏阴性菌之间发现了明显的数量差异。新型大环内酯类抗生素罗红霉素尚未证实有PAE。因此，我们在体外比较了罗红霉素、红霉素和克林霉素对金黄色葡萄球菌、化脓性链球菌、肺炎链球菌和流感嗜血杆菌的实验室菌株及临床分离株的PAE。对三种受试药物而言，相同的MIC倍数和相同的暴露时间产生了相似的PAE。体外浓度-时间曲线下面积（AUC）与PAE之间存在良好的相关性。肺炎链球菌在1.9mg/l罗红霉素中暴露6小时后观察到最长的PAE为9.6小时。
