Vázquez-Doval J, Ruiz de Erenchun F, Sánchez-Ibarrola A, Contreras F, Soto de Delás J, Quintanilla E
Department of Dermatology, University of Navarra, Pamplona, Spain.
J Investig Allergol Clin Immunol. 1992 Jan-Feb;2(1):27-32.
Subacute cutaneous lupus erythematosus (SCLE) is a recently described distinct subset of lupus erythematosus (LE) having characteristic clinical, serological and genetic features. The clinicopathological and serological findings of 5 patients are reported. From a clinical point of view, we describe two types of cutaneous lesions: psoriasiform and annular pattern. ANA were present in 80% of the cases, anti-Ro was present in 60%, and anti-La in 20%; anti-RNP was positive in 1 patient. Circulating immune complexes were detected in 2 patients, and low levels of complement factors (C3, C4) in another 2 patients. The B- cell alloantigens HLA-A2, HLA-Bw4 or HLA-DR3 were present in 60% of the cases. The cutaneous histopathology revealed important changes in the epidermis. Our findings are similar to those described by most other authors. Also, we would like to emphasize the low disease activity and benign course of our patients.
亚急性皮肤型红斑狼疮（SCLE）是最近描述的一种独特的红斑狼疮（LE）亚型，具有特征性的临床、血清学和遗传学特征。本文报告了5例患者的临床病理和血清学检查结果。从临床角度来看，我们描述了两种皮肤损害类型：银屑病样和环状皮损。80%的病例抗核抗体（ANA）阳性，60%抗Ro抗体阳性，20%抗La抗体阳性；1例患者抗核糖核蛋白（RNP）抗体阳性。2例患者检测到循环免疫复合物，另外2例患者补体因子（C3、C4）水平降低。60%的病例存在B细胞同种异体抗原HLA - A2、HLA - Bw4或HLA - DR3。皮肤组织病理学显示表皮有重要变化。我们的研究结果与大多数其他作者描述的相似。此外，我们想强调我们的患者疾病活动度低且病程良性。
