Marschalkó M, Dobozy E, Daróczy J, Gyimesi E, Horváth A
Orv Hetil. 1989 Dec 3;130(49):2623-8.
15 cases of subacute cutaneous lupus erythematosus are reported. The diagnosis was based on the presence of the typical clinical features, on the histologic and immunpathologic examination of lesional skin and on the characteristic laboratory findings. 8 patients had annular type, 4 patients had papulosquamosus type of the characteristic skin signs of subacute cutaneous lupus erythematosus. In 3 patients both types of lesions existed simultaneously. 5 patients fulfilled the American Rheumatism Association criteria for systemic lupus erythematosus, however the systemic symptoms (arthritis, arthralgia, fever, myalgia, photosensitivity) were mild. 4 patients had positive ANA test, anti-Ro/SSA antibodies were determined in 5 patients, anti-RNP antibodies were detected in 8 patients. Anti-dsDNA antibodies were not detected. Subacute cutaneous lupus erythematosus is an intermediate subset in severity between discoid lupus erythematosus and severe systemic lupus erythematosus, therefore a milder form of therapy should be chosen.
报告了15例亚急性皮肤型红斑狼疮病例。诊断基于典型临床特征的存在、皮损的组织学和免疫病理学检查以及特征性实验室检查结果。8例患者为环形，4例患者为丘疹鳞屑型亚急性皮肤型红斑狼疮的特征性皮肤体征。3例患者两种皮损同时存在。5例患者符合美国风湿病学会系统性红斑狼疮的标准，但全身症状（关节炎、关节痛、发热、肌痛、光敏性）较轻。4例患者抗核抗体检测呈阳性，5例患者检测到抗Ro/SSA抗体，8例患者检测到抗RNP抗体。未检测到抗双链DNA抗体。亚急性皮肤型红斑狼疮在严重程度上是盘状红斑狼疮和重度系统性红斑狼疮之间的中间亚型，因此应选择较温和的治疗方式。
