Urdaneta-Morales S, Tejero F
Seccion de Parasitologia, Instituto de Zoologia Tropical, Facultad de Ciencias, Universidad Central de Venezuela, Caracas.
Mem Inst Oswaldo Cruz. 1992 Oct-Dec;87(4):511-6. doi: 10.1590/s0074-02761992000400008.
Meta-trypomastigotes of Trypanosoma rangeli Tejera, 1920, harvested from LIT medium, were inoculated i.p. or s.c. into 6, 16, and 26 g NMRI mice, these representing increasing degrees of immunological maturity. In all cases, similar pleomorphic patterns were observed. Four morphobiometrically differentiable types of trypanosome were encountered in an overlapping temporal sequence. These observations, taken in comparison with those on pleomorphism in this and other species of Trypanosoma by other workers, are consistent with the hypothesis that the pleomorphic types represent the natural development of the parasite, rather than the result of the immune response of the mammal host. Small, slender trypanosomes prevalent at the onset of the parasitemia either reinvade the tissue cells for relatively limited subsequent generations of tissue reproduction, or else differentiate toward the forms that are only capable of colonizing the insect vector.
1920年特耶拉描述的兰氏锥虫的中型锥鞭毛体，从LIT培养基中收获后，通过腹腔注射或皮下注射接种到体重分别为6克、16克和26克的NMRI小鼠体内，这些小鼠代表了免疫成熟程度不断增加的情况。在所有情况下，均观察到相似的多形性模式。在一个重叠的时间序列中遇到了四种形态计量学上可区分的锥虫类型。与其他研究人员对该种及其他锥虫属物种多形性的观察结果相比，这些观察结果与以下假设一致，即多形性类型代表寄生虫的自然发育，而非哺乳动物宿主免疫反应的结果。在虫血症开始时普遍存在的小而细长的锥虫，要么重新侵入组织细胞进行相对有限的后续几代组织繁殖，要么分化为仅能在昆虫媒介中定殖的形态。
