艾氏腹水瘤细胞胞质内病毒样颗粒的形态学与分布的电子显微镜研究
An electron microscope study of the morphology and distribution of the intracytoplasmic virus-like particles of Ehrlich ascites tumor cells.
作者信息
ADAMS W R, PRINCE A M
出版信息
J Biophys Biochem Cytol. 1957 Mar 25;3(2):161-70. doi: 10.1083/jcb.3.2.161.
Abstract
Electron microscope studies of eight different sublines of Ehrlich ascites tumor cells which had not, as far as could be determined, come in contact with any known virus, revealed dense particles measuring approximately 55 to 70 mmicro in diameter, both within and attached to the wall of cytoplasmic vesicles identified as the endoplasmic reticulum. All tumor sublines contained significant numbers of particles and revealed no qualitative or quantitative differences in particle morphology or distribution. It is concluded that these structures are a constant morphological component of the Ehrlich ascites tumor and that they probably do not represent contaminating virus. Their morphology and distribution are described, and the possible interpretations of their significance are discussed.
摘要
对八种不同亚系的艾氏腹水瘤细胞进行电子显微镜研究，据测定，这些细胞未接触过任何已知病毒，结果显示，在被确定为内质网的细胞质小泡壁内及附着于其上，存在直径约为55至70毫微米的致密颗粒。所有肿瘤亚系均含有大量颗粒，且在颗粒形态或分布上未显示出质或量的差异。得出的结论是，这些结构是艾氏腹水瘤恒定的形态学组成部分，它们可能并不代表污染病毒。描述了它们的形态和分布，并讨论了对其意义的可能解释。
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本文引用的文献
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Virus-like particles associated with the Rous sarcoma as seen in sections of tumor.在肿瘤切片中所见的与劳斯肉瘤相关的病毒样颗粒。
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