PILLEMER L, LANDY M, SHEAR M J
J Exp Med. 1957 Jul 1;106(1):99-110. doi: 10.1084/jem.106.1.99.
High molecular weight polysaccharide complexes derived from normal and neoplastic mammalian tissues were found to combine with properdin and to inactivate C'3 in vitro. These polysaccharide preparations were also found to alter properdin levels and non-specific resistance to Gram-negative infection in mice. In these manifestations, the tissue polysaccharides bore a marked resemblance to bacterial lipopolysaccharides. Some implications of the interactions of tissue polysaccharides and properdin in certain disease states are considered.
研究发现,源自正常和肿瘤性哺乳动物组织的高分子量多糖复合物可与备解素结合,并在体外使C'3失活。还发现这些多糖制剂可改变小鼠的备解素水平以及对革兰氏阴性菌感染的非特异性抵抗力。在这些表现中,组织多糖与细菌脂多糖有明显相似之处。本文考虑了组织多糖与备解素相互作用在某些疾病状态中的一些影响。