LANDY M, PILLEMER L
J Exp Med. 1956 Sep 1;104(3):383-409. doi: 10.1084/jem.104.3.383.
It has been shown that injection of lipopolysaccharides, derived from a variety of Gram-negative bacterial species, evokes in mice a rapidly developing rise in resistance to infection with Gram-negative pathogens. This is accompanied by an elevation in properdin titer, at times to levels 2 to 3 times the normal. The rate, magnitude, and duration of these responses are dependent on many factors, the most important of which are the quantity and timing of the lipopolysaccharide administered. The increased resistance to infection evoked in mice by lipopolysaccharides was effective against infections produced by endotoxin-bearing organisms-bacterial species highly susceptible in vitro to the bactericidal action of the properdin system. Properdin titers of mice prior to infection provide an incomplete picture of the subsequent reaction of the host to the infective agent. Following infection with Gram-negative organisms, properdin levels accurately reflect the bacteriologic course and outcome of the infection. Thus, in control animals, properdin titers progressively declined and the animals died, while in mice appropriately treated with lipopolysaccharide, properdin levels were either maintained in the normal range or increased, depending on the dose and time of administration of lipopolysaccharide; this was always accompanied by successful management of the infection. The complex nature of the alterations produced in the host by lipopolysaccharides is stressed. It is pointed out that the increase in the ability of the host to cope with Gram-negative infections may be the result of stimulation of other defense mechanisms, in addition to the properdin system.
已经表明，注射源自多种革兰氏阴性细菌的脂多糖，会使小鼠对革兰氏阴性病原体感染的抵抗力迅速增强。这伴随着备解素滴度的升高，有时可达到正常水平的2至3倍。这些反应的速率、幅度和持续时间取决于许多因素，其中最重要的是所给予脂多糖的数量和时间。脂多糖在小鼠中引起的对感染抵抗力的增加，对由携带内毒素的生物体产生的感染有效，这些细菌种类在体外对备解素系统的杀菌作用高度敏感。感染前小鼠的备解素滴度并不能完全反映宿主随后对感染因子的反应。感染革兰氏阴性生物体后，备解素水平准确反映了感染的细菌学过程和结果。因此，在对照动物中，备解素滴度逐渐下降，动物死亡，而在用脂多糖适当处理的小鼠中，备解素水平要么维持在正常范围内，要么升高，这取决于脂多糖的剂量和给药时间；这总是伴随着感染的成功控制。强调了脂多糖在宿主中产生的变化的复杂性。指出宿主应对革兰氏阴性感染能力的增强可能是除备解素系统外其他防御机制受到刺激的结果。
