Hillerdal G, Frisk G, Nettelbladt O, Diderholm H
Department of Lung Medicine, University Hospital, Uppsala, Sweden.
Sarcoidosis. 1992 Mar;9(1):39-42.
By using radioimmunoassay (RIA) for detection of IgM antibodies to Coxsackie B viruses (CBV), the occurrence of these antibodies was investigated in patients with sarcoidosis and asbestos-related lesions. Sixty-one per cent of the patients with sarcoidosis, all patients with benign asbestos pleural effusion, and 67% of those with diffuse asbestos-related pleural thickening showed CBV-IgM. Patients with healed sarcoidosis or pleural plaques were all negative, and among the "healthy" controls seven per cent had CBV-IgM. Thus, there was a high frequency of CBV-IgM in patients with sarcoidosis and in those with asbestos-related diseases. Since the titres could be the effect of an unspecific polyclonal stimulation of the B cells, sera were tested for antibodies to rubella and cytomegalovirus, but without any remarkable results.
通过使用放射免疫分析法（RIA）检测柯萨奇B病毒（CBV）的IgM抗体，对结节病患者和石棉相关病变患者中这些抗体的出现情况进行了研究。61%的结节病患者、所有良性石棉性胸腔积液患者以及67%的弥漫性石棉相关胸膜增厚患者显示出CBV-IgM。结节病已愈合或有胸膜斑的患者均为阴性，在“健康”对照者中，7%有CBV-IgM。因此，结节病患者和石棉相关疾病患者中CBV-IgM的频率较高。由于这些滴度可能是B细胞非特异性多克隆刺激的结果，因此检测了血清中的风疹和巨细胞病毒抗体，但没有任何显著结果。
