Bolanowski J, Spring A, Tupikowska G
Katedry i Kliniki Kardiologii Ak. Med, Wrocławiu.
Wiad Lek. 1992 Dec;45(23-24):883-6.
In 20 patients with acromegaly, morphology of the heart and its systolic and diastolic function were studied by echocardiography, and growth hormone concentration was examined in the serum. Increased muscle mass of the left ventricle was found and that increase depended on disease duration and the growth hormone serum concentration. An increase was also shown of the left ventricular end-diastolic dimension, and the dimensions of left ventricle posterior wall and intraventricular septum, as well as an increase of end-systolic left ventricular dimension and of the size of the left atrium. Out of systolic function parameters, an increase was shown of stroke volume, cardiac output and cardiac index. In 40% of the studied patients an impairment was shown of left ventricular diastolic function but in a half of them no diseases other than acromegaly were found which could have been its cause.
对20例肢端肥大症患者，采用超声心动图研究心脏形态及其收缩和舒张功能，并检测血清生长激素浓度。发现左心室肌肉质量增加，且这种增加取决于病程和血清生长激素浓度。左心室舒张末期内径、左心室后壁和室间隔尺寸也增加，以及收缩末期左心室尺寸和左心房大小增加。在收缩功能参数中，每搏输出量、心输出量和心脏指数增加。在40%的研究患者中，左心室舒张功能受损，但其中一半患者除肢端肥大症外未发现其他可能导致舒张功能受损的疾病。
