Iida K, Koide Y, Sugishita Y, Matsuda M, Kawai K, Yukisada K, Tomono Y, Yamashita K, Ito I
Department of Internal Medicine, University of Tsukuba, Japan.
Jpn J Med. 1990 Jan-Feb;29(1):22-6. doi: 10.2169/internalmedicine1962.29.22.
Pre-operative and post-operative echocardiographic data were analyzed from 8 patients with acromegaly. Pre-operatively, end-diastolic diameter was greater than 55 mm in 5 patients (63%) and concentric left ventricular hypertrophy was observed in 3 patients (38%). However, left ventricular function was normal (fractional shortening of the left ventricle greater than 28%) in all patients except 1. All patients had increased left ventricular mass. There was no significant correlation between left ventricular mass and basal plasma growth hormone concentration. An average of 23.9 months after hypophysectomy, growth hormone concentration was significantly decreased. However, the abnormal echocardiographic findings remained. In conclusion, echocardiographic abnormalities (left ventricular dilatation and hypertrophy) are common in patients with acromegaly, but systolic function is, in general, maintained. These cardiac abnormalities persist after reduction of plasma growth hormone concentration.
对8例肢端肥大症患者的术前和术后超声心动图数据进行了分析。术前，5例患者（63%）的舒张末期直径大于55 mm，3例患者（38%）观察到同心性左心室肥厚。然而，除1例患者外，所有患者的左心室功能均正常（左心室缩短分数大于28%）。所有患者的左心室质量均增加。左心室质量与基础血浆生长激素浓度之间无显著相关性。垂体切除术后平均23.9个月，生长激素浓度显著降低。然而，超声心动图异常表现仍然存在。总之，超声心动图异常（左心室扩张和肥厚）在肢端肥大症患者中很常见，但总体上收缩功能得以维持。血浆生长激素浓度降低后，这些心脏异常仍然存在。
