Lacka K, Piszczek I, Kosowicz J, Gembicki M
Department of Endocrinology, Medical Academy, Poznań/Poland.
Exp Clin Endocrinol. 1988 May;91(2):212-6. doi: 10.1055/s-0029-1210747.
The aim of our study was the evaluation of the cardiac size and left ventricular function in 26 patients with acromegaly and 20 control subjects using echocardiography. The following parameters were evaluated: systolic and diastolic ventricular dimensions, diastolic posterior wall and interventricular septal thickness, left ventricle ejection fraction and left ventricular mass, amplitude of the posterior left ventricular wall movement, speed of the circular fibres shortening area of the left ventricular muscle and left ventricular contractility index.
In 91% of patients with acromegaly echocardiographic abnormalities were found. The most frequent were: concentric thickening of the left ventricular posterior wall in 38%, interventricular septal thickening in 54% and increased left ventricular mass in 84.6% of acromegalic patients. Left ventricular dimensions were increased: diastolic in 65.4% and systolic in 92% of patients. In 46% of cases the ejection fraction was decreased. There was no correlation between extent of the left ventricular hypertrophy and other echocardiographic abnormalities, serum growth hormone concentration, choice of therapy and duration of the disease.
我们研究的目的是使用超声心动图评估26例肢端肥大症患者和20例对照者的心脏大小及左心室功能。评估了以下参数：心室收缩期和舒张期内径、舒张期后壁厚度和室间隔厚度、左心室射血分数和左心室质量、左心室后壁运动幅度、左心室心肌环形纤维缩短面积速度以及左心室收缩性指数。
在91%的肢端肥大症患者中发现了超声心动图异常。最常见的异常为：38%的患者左心室后壁同心性增厚，54%的患者室间隔增厚，84.6%的肢端肥大症患者左心室质量增加。左心室内径增大：65.4%的患者舒张期内径增大，92%的患者收缩期内径增大。46%的病例射血分数降低。左心室肥厚程度与其他超声心动图异常、血清生长激素浓度、治疗选择及病程之间无相关性。
