Gómez-Flores R, Tamez-Guerra R
Departamento de Microbiología e Inmunología, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, México.
Rev Latinoam Microbiol. 1992 Jan-Mar;34(1):67-70.
The production of substances by lymphocytes or macrophages under activation involved in regulating immune responses, has led us to study a new macrophage factor with chemotactic activity for lymphocytes. This factor is produced early in the immune response activation (6 hours, in vitro) by peritoneal exudate adherent cells under stimulation with sheep red blood cells (SRBC) and it induces lymphocyte chemotaxis. We have confirmed this factor is a polypeptide susceptible to proteolytic digestion. Besides, its receptor on T cells requires the presence of glycosylated sites, specially sialic acid. It was determined that such a chemotactic factor was not interleukin-1, a well-characterized mitogenic and chemotactic substance for T lymphocytes.
淋巴细胞或巨噬细胞在激活状态下产生的参与调节免疫反应的物质，促使我们去研究一种对淋巴细胞具有趋化活性的新型巨噬细胞因子。该因子在免疫反应激活早期（体外6小时）由腹膜渗出液贴壁细胞在绵羊红细胞（SRBC）刺激下产生，并诱导淋巴细胞趋化。我们已证实该因子是一种易受蛋白水解酶消化的多肽。此外，其在T细胞上的受体需要糖基化位点的存在，特别是唾液酸。已确定这种趋化因子不是白细胞介素-1，白细胞介素-1是一种已被充分表征的对T淋巴细胞具有促有丝分裂和趋化作用的物质。
