Hijiya N, Gewirtz A M
Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia 19104.
J Hematother. 1992 Winter;1(4):369-78. doi: 10.1089/scd.1.1992.1.369.
Retroviruses are known to carry specific genes that are likely to be responsible for induction of the malignant phenotype in the cells they infect. These genes, termed viral oncogenes (v-onc), have subsequently been shown to be derived from highly conserved, normal cellular genes commonly referred to as proto-oncogenes (c-onc). Proto-oncogenes are thought to be intimately involved in the processes of cell proliferation and differentiation. Therefore, any c-onc amplification, mutation, structural alteration, or change in transcriptional regulation might lead to, or be associated with, induction of a malignant phenotype. Targeted disruption of these genes may therefore be of therapeutic value. We discuss the role of antisense DNA in carrying out such therapy.
已知逆转录病毒携带特定基因，这些基因可能是其所感染细胞中恶性表型诱导的原因。这些基因被称为病毒癌基因（v-onc），随后被证明源自高度保守的正常细胞基因，通常称为原癌基因（c-onc）。原癌基因被认为与细胞增殖和分化过程密切相关。因此，任何c-onc的扩增、突变、结构改变或转录调控变化都可能导致或与恶性表型的诱导相关。因此，对这些基因进行靶向破坏可能具有治疗价值。我们讨论了反义DNA在实施这种治疗中的作用。
