Zhu X F, Shi Y F, Zhang J X, Harris A G
Department of Endocrinology, Pekin Union Medical College Hospital, Beijing, China.
Dig Dis Sci. 1992 Jan;37(1):105-8. doi: 10.1007/BF01308351.
The acute effects of single different doses of the somatostatin analog octreotide on the contractility of the gallbladder stimulated by fatty meal were studied in six healthy Chinese volunteers. Gallbladder contraction after a fatty meal was significantly suppressed by octreotide at doses of 50, 25, 12.5, and 5 micrograms. Mean duration of suppression lasted for more than 10 hr at doses of 25 and 50 micrograms, after which the gallbladder contractility was restored at 24 hr in three and four, respectively, of the six subjects. The percentage of relative gallbladder contraction (PRGC) in all subjects receiving 12.5 and 5 micrograms octreotide returned to pretreatment values at 10 hr but had not returned to normal 6 hr after the injection of 5 micrograms octreotide. In summary, octreotide inhibits the contraction of the gallbladder even with a dose as low as 5 micrograms. It appears that it may not be possible to avoid gallbladder dysfunction during long-term octreotide therapy by decreasing the dose. Further studies including modalities to increase the contractility of the gallbladder are recommended.
在6名健康中国志愿者中研究了单一不同剂量的生长抑素类似物奥曲肽对脂肪餐刺激的胆囊收缩力的急性影响。剂量为50、25、12.5和5微克的奥曲肽可显著抑制脂肪餐后的胆囊收缩。25和50微克剂量时，平均抑制持续时间超过10小时，6名受试者中分别有3名和4名在24小时时胆囊收缩力恢复。接受12.5和5微克奥曲肽的所有受试者的相对胆囊收缩百分比（PRGC）在10小时时恢复到治疗前值，但在注射5微克奥曲肽6小时后未恢复正常。总之，奥曲肽即使在低至5微克的剂量下也能抑制胆囊收缩。似乎通过降低剂量可能无法避免长期奥曲肽治疗期间的胆囊功能障碍。建议进行进一步研究，包括增加胆囊收缩力的方法。
