Grimaldi C, Darcourt J, Harris A G, Lebot E, Lapalus F, Delmont J
Cabinet d'Hépato-Gastro-Entérologie, Nice, France.
Dig Dis Sci. 1993 Sep;38(9):1718-21. doi: 10.1007/BF01303183.
The objective of the study was to investigate the effects of a single intravenous injection of the somatostatin analog octreotide on hepatic bile secretion and gallbladder emptying with a quantitative scintigraphic technique. Twelve healthy volunteers received, in a double-blind randomized fashion, either octreotide, 100 micrograms intravenously, or placebo. Ten minutes later, [99mTc]PBIDA was administered intravenously (50 microCi/kg) (time = 0) followed, 60 min later, by the ingestion of a standardized fatty meal. In the liver area, the relative decrease per minute of tracer activity from the time of maximal activity to 60 min was significantly lower in the octreotide group (P = 0.02). In the gallbladder area, after the fatty meal, the ratio of tracer activity at 60 and 90 min (A90/A60) was significantly (P = 0.01) higher in the octreotide group. Our study demonstrates that octreotide slows down liver release of the radiopharmaceutical, probably reflecting decreased bile secretion, and inhibits postprandial gallbladder contraction.
本研究的目的是采用定量闪烁扫描技术，研究单次静脉注射生长抑素类似物奥曲肽对肝脏胆汁分泌和胆囊排空的影响。12名健康志愿者以双盲随机方式，静脉注射100微克奥曲肽或安慰剂。10分钟后，静脉注射[99mTc]PBIDA（50微居里/千克）（时间=0），60分钟后，摄入标准化脂肪餐。在肝脏区域，从最大活性时间到60分钟，奥曲肽组示踪剂活性每分钟的相对下降显著更低（P=0.02）。在胆囊区域，脂肪餐后，奥曲肽组60分钟和90分钟时的示踪剂活性比（A90/A60）显著更高（P=0.01）。我们的研究表明，奥曲肽减缓了放射性药物从肝脏的释放，这可能反映了胆汁分泌减少，并抑制了餐后胆囊收缩。
