Fisher R S, Rock E, Levin G, Malmud L
Gastroenterology. 1987 Apr;92(4):885-90. doi: 10.1016/0016-5085(87)90961-9.
Because approximately 80% of reported patients with somatostatinomas have gallstones, this study was performed to determine the effects of exogenous somatostatin on gallbladder emptying responses to liquid and solid meals, direct cholinergic stimulation by bethanechol, indirect cholinergic stimulation by sham feeding, and intravenously administered octapeptide of cholecystokinin. Gallbladder emptying was quantitated using 99mTc-HIDA and a gamma-camera on line to a digital computer. Somatostatin, administered at a dosage of 7 micrograms/kg X h, prevented the gallbladder emptying responses to both test meals, sham feeding, and bethanechol. The maximal gallbladder emptying response to octapeptide of cholecystokinin at 5.0 ng/kg X min was reduced from 93.2% +/- 4.8% to 57.1% +/- 9.9% (p less than 0.01) and to octapeptide of cholecystokinin at 0.5 ng/kg X min from 91.3% +/- 5.3% to 14.8% +/- 4.2% (p less than 0.01). These findings suggest that somatostatin is a potent inhibitor of gallbladder emptying in humans. This may be an important factor in the development of gallstones in patients with somatostatinomas.
由于在报告的生长抑素瘤患者中约80%有胆结石，因此进行本研究以确定外源性生长抑素对胆囊对液体和固体餐的排空反应、氨甲酰甲胆碱直接胆碱能刺激、假饲间接胆碱能刺激以及静脉注射胆囊收缩素八肽的影响。使用99mTc-HIDA和与数字计算机联机的γ相机对胆囊排空进行定量。以7微克/千克·小时的剂量给予生长抑素，可抑制胆囊对两种试验餐、假饲和氨甲酰甲胆碱的排空反应。胆囊对5.0纳克/千克·分钟胆囊收缩素八肽的最大排空反应从93.2%±4.8%降至57.1%±9.9%（p<0.01），对0.5纳克/千克·分钟胆囊收缩素八肽的最大排空反应从91.3%±5.3%降至14.8%±4.2%（p<0.01）。这些发现表明生长抑素是人类胆囊排空的有效抑制剂。这可能是生长抑素瘤患者胆结石形成的一个重要因素。
