van Furth R, van't Wout J W, Wertheimer P A, Zwartendijk J
Department of Infectious Diseases, University Hospital Leiden, Netherlands.
Lancet. 1992 Jan 18;339(8786):148-9. doi: 10.1016/0140-6736(92)90212-l.
The tumour-like lesions of the rare disease malakoplakia, which consist of macrophages containing undigested coliform bacteria, are often misdiagnosed as a carcinoma. Although an infectious aetiology is likely, no antimicrobial therapy has been successful in the long-term. Since ciprofloxacin penetrates well into macrophages, this drug was given to two patients with advanced malakoplakia (500 mg twice daily). After long-term treatment all granulomatous lesions disappeared. Thus, malakoplakia can be cured by antibiotic treatment.
罕见疾病软斑病的肿瘤样病变由含有未消化大肠菌的巨噬细胞组成，常被误诊为癌。尽管其病因可能是感染性的，但长期来看，抗菌治疗均未成功。由于环丙沙星能很好地渗透到巨噬细胞中，给予了两名晚期软斑病患者该药（每日两次，每次500毫克）。经过长期治疗，所有肉芽肿性病变均消失。因此，软斑病可用抗生素治愈。
