多种胆碱酯酶对咪唑丙烯酰胆碱（墨角藻碱）和咪唑丙酰胆碱（二氢墨角藻碱）的酶促水解作用。

The enzymatic hydrolysis of imidazoleacryloylcholine (murexine) and imidazolepropionylcholine (dihydromurexine) by various cholinesterases.

作者信息

GRELIS M E, TABACHNICK I I

出版信息

Br J Pharmacol Chemother. 1957 Sep;12(3):320-2. doi: 10.1111/j.1476-5381.1957.tb00141.x.

DOI:10.1111/j.1476-5381.1957.tb00141.x

PMID:13460237

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1509698/

Abstract

Several choline esters, including the imidazoleacryloyl and imidazolepropionyl compounds, have been hydrolysed by cholinesterases from various sources. The imidazolepropionyl ester was metabolized by cholinesterases obtained from human plasma, ox spleen, ox serum, and guinea-pig liver, but not by rat liver or bovine red cell cholinesterase. It is suggested the imidazolepropionylcholine or a closely related ester might be the natural substrate for "non-specific" cholinesterase.

摘要

包括咪唑丙烯酰化合物和咪唑丙酰化合物在内的几种胆碱酯已被来自不同来源的胆碱酯酶水解。咪唑丙酰酯可被从人血浆、牛脾脏、牛血清和豚鼠肝脏中获得的胆碱酯酶代谢，但不能被大鼠肝脏或牛红细胞胆碱酯酶代谢。有人提出咪唑丙酰胆碱或一种密切相关的酯可能是“非特异性”胆碱酯酶的天然底物。