BROWN R V
Br J Pharmacol Chemother. 1960 Mar;15(1):170-4. doi: 10.1111/j.1476-5381.1960.tb01227.x.
Dogs poisoned by the anticholinesterase sarin could be saved by intravenous administration of atropine sulphate together with a suitable oxime. The central effects of intracisternal sarin were respiratory paralysis and vasomotor stimulation. The problem arose as to whether the oxime, being a quaternary nitrogen compound, could enter the brain from the blood, and could have a central action on the paralysed respiration. The methyl methanesulphonate of pyridine-2-aldoxime administered intracisternally, after sarin poisoning by the same route, was ineffective; atropine, given intravenously, was effective. The central and peripheral effects of sarin were thus reversed by the atropine-oxime therapy, the central effects by atropine, the peripheral by the oxime.
被抗胆碱酯酶沙林中毒的狗，通过静脉注射硫酸阿托品和合适的肟可以获救。脑池内注射沙林的中枢效应是呼吸麻痹和血管运动刺激。问题在于，肟作为一种季铵氮化合物，能否从血液进入大脑，并对麻痹的呼吸产生中枢作用。在通过相同途径用沙林中毒后，脑池内注射吡啶 -2-醛肟甲磺酸甲酯无效；静脉注射阿托品有效。因此，阿托品 -肟疗法可逆转沙林的中枢和外周效应，阿托品逆转中枢效应，肟逆转外周效应。
