某些肟类药物在沙林中毒中的作用。
The effect of some oximes in sarin poisoning.
作者信息
RUTLAND J P
出版信息
Br J Pharmacol Chemother. 1958 Dec;13(4):399-403. doi: 10.1111/j.1476-5381.1958.tb00228.x.
Abstract
The effects of monoisonitrosoacetone (MINA), diacetylmonoxime (DAM) and pyridine-2-aldoxime methiodide (P2AM) upon the cholinesterase of sarin poisoned rats have been studied. Monoisonitrosoacetone and diacetylmonoxime given before sarin protected blood and brain cholinesterase from inhibition. Monoisonitrosoacetone given after the appearance of signs of poisoning caused a rapid reactivation of brain cholinesterase. Diacetylmonoxime, at an equimolar dose, produced only a slight increase in enzyme activity, and pyridine-2-aldoxime methiodide, the best reactivator in vitro, reactivated blood but not brain cholinesterase. There is a relationship between protection and reactivation of brain cholinesterase and prevention and alleviation of signs of poisoning.
摘要
研究了单异亚硝基丙酮（MINA）、双乙酰一肟（DAM）和吡啶 -2-醛肟甲基碘（P2AM）对沙林中毒大鼠胆碱酯酶的影响。在沙林之前给予单异亚硝基丙酮和双乙酰一肟可保护血液和脑胆碱酯酶免受抑制。中毒迹象出现后给予单异亚硝基丙酮可使脑胆碱酯酶迅速重新活化。双乙酰一肟在等摩尔剂量时仅使酶活性略有增加，而体外最佳重新活化剂吡啶 -2-醛肟甲基碘可使血液胆碱酯酶重新活化，但不能使脑胆碱酯酶重新活化。脑胆碱酯酶的保护和重新活化与中毒迹象的预防和减轻之间存在关联。
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本文引用的文献
1
The location of cholinesterase in the central nervous system.胆碱酯酶在中枢神经系统中的位置。
Q J Exp Physiol Cogn Med Sci. 1952;37(2):61-74. doi: 10.1113/expphysiol.1952.sp000983.
2
The cerebral distributions of a tertiary and a quaternary anticholinesterase agent following intravenous and intraventricular injection.静脉注射和脑室内注射后一种叔胺类和一种季铵类抗胆碱酯酶药物的脑部分布情况。
J Pharmacol Exp Ther. 1956 Dec;118(4):420-34.
3
The nature of the toxicity of 2-oxo-oximes.2-氧代肟的毒性本质。
Br J Pharmacol Chemother. 1956 Dec;11(4):424-7. doi: 10.1111/j.1476-5381.1956.tb00010.x.
4
Oximes and hydroxamic acids as antidotes in anticholinesterase poisoning.肟类和异羟肟酸类作为抗胆碱酯酶中毒的解毒剂。
Br J Pharmacol Chemother. 1956 Dec;11(4):417-23. doi: 10.1111/j.1476-5381.1956.tb00009.x.
5
The reactivation by oximes and hydroxamic acids of cholinesterase inhibited by organo-phosphorus compounds.肟类和异羟肟酸类化合物对有机磷化合物抑制的胆碱酯酶的复活作用。
Br J Pharmacol Chemother. 1955 Dec;10(4):462-5. doi: 10.1111/j.1476-5381.1955.tb00106.x.
6
Return of cholinesterase activity in the rat after inhibition by organophosphorus compounds. I. Diethyl p-nitro-phenyl phosphate (E 600, paraoxon).大鼠体内胆碱酯酶活性在被有机磷化合物抑制后的恢复。I. 对硝基苯基二乙酯（E 600，对氧磷）。
Biochem J. 1953 Jul;54(4):583-90. doi: 10.1042/bj0540583.
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