Gunshefski L A, Rifley W J, Slattery D W, Schifini J J, Hartsuck M, Little A G
Department of Surgery, University of Nevada School of Medicine, Las Vegas.
Am J Surg. 1992 Jan;163(1):59-62. doi: 10.1016/0002-9610(92)90253-n.
The inhibitory effects of somatostatin on gastric and small bowel motor function are well documented. However, the effects of somatostatin on esophageal body motility and lower esophageal sphincter tone are not completely defined. We investigated the effects of octreotide, a long-acting somatostatin analogue, on the esophageal body and the lower esophageal sphincter in 15 healthy volunteers. Lower esophageal sphincter tone was increased by octreotide infusion. Esophageal body contraction amplitude and velocity were also increased by octreotide infusion. Our data show that somatostatin stimulates the normal human esophagus, an action mediated either by a direct effect, a central nervous system action, or the inhibition of the secretion of gastrointestinal hormones that influence esophageal motor activity.
生长抑素对胃和小肠运动功能的抑制作用已有充分文献记载。然而，生长抑素对食管体部蠕动和食管下括约肌张力的影响尚未完全明确。我们研究了长效生长抑素类似物奥曲肽对15名健康志愿者食管体部和食管下括约肌的影响。输注奥曲肽可增加食管下括约肌张力。输注奥曲肽还可增加食管体部收缩幅度和速度。我们的数据表明，生长抑素刺激正常人体食管，这一作用是由直接效应、中枢神经系统作用或抑制影响食管运动活动的胃肠激素分泌介导的。
