Barrioz T, Borderie C, Strock P, Ingrand P, Fort E, Silvain C, Beauchant M
Service d'Hépato-gastroentérologie, Centre Hospitalier Universitaire, Poitiers, France.
Dig Dis Sci. 1998 Jul;43(7):1566-71. doi: 10.1023/a:1018879218508.
We investigated the effects of octreotide infusion on the contractile activity of the esophageal body and lower esophageal sphincter in cirrhotic patients with esophageal varices. Esophageal manometry was performed in 36 alcoholic cirrhotic patients. They were randomly allocated to three groups and received the following treatments blindly for 90 min: an initial 100-microg intravenous bolus followed by a continuous 25 microg/hr octreotide infusion (group I, N= 13), a continuous 25 micro/hr octreotide infusion without an initial bolus (group II, N=13), and a continuous placebo infusion (group III, N=10). Before drug infusion, mean lower esophageal sphincter pressure and mean esophageal body contraction pressure and duration were similar in the three groups. Compared to the placebo group, lower esophageal sphincter pressure increased significantly in groups I and II, 30 min (30%, 22%, 3% respectively; P= 0.006), 60 min (44%, 35%, 0.6%; P=0.0002), and 90 min (67%, 41%, 2.5%; P=0.0001) after octreotide infusion, as did esophageal body contraction pressure and duration. We conclude that octreotide has a potent effect on LES tone in cirrhotic patients.
我们研究了奥曲肽输注对肝硬化食管静脉曲张患者食管体部和食管下括约肌收缩活动的影响。对36例酒精性肝硬化患者进行了食管测压。他们被随机分为三组，并接受以下盲法治疗90分钟：初始静脉推注100微克，随后以25微克/小时的速度持续输注奥曲肽（第一组，N = 13）；不进行初始推注，以25微克/小时的速度持续输注奥曲肽（第二组，N = 13）；持续输注安慰剂（第三组，N = 10）。在药物输注前，三组的食管下括约肌平均压力、食管体部平均收缩压力和持续时间相似。与安慰剂组相比，在输注奥曲肽后30分钟（分别为30%、22%、3%；P = 0.006）、60分钟（44%、35%、0.6%；P = 0.0002）和90分钟（67%、41%、2.5%；P = 0.0001）时，第一组和第二组的食管下括约肌压力显著升高，食管体部收缩压力和持续时间也显著升高。我们得出结论，奥曲肽对肝硬化患者的LES张力有显著影响。
