Inoue M, Fujita M, Nakazawa A, Ogawa H, Tanizawa O
Department of Obstetrics and Gynecology, Osaka University Medical School, Japan.
Obstet Gynecol. 1992 Mar;79(3):434-40. doi: 10.1097/00006250-199203000-00022.
Serum sialyl-Tn, sialyl-Lewis Xi, CA 19-9, CA 125, carcinoembryonic antigen (CEA), and tissue polypeptide antigen were measured in 65 women with early-stage ovarian cancer (45 stage I and 20 stage II cases) and 317 with benign pelvic masses. As a single assay, sialyl-Tn showed the best sensitivity and specificity, 46 and 92%, respectively. CA 19-9 detected the greatest number of cancer patients but had the lowest specificity. The combination of sialyl-Tn, CA 125, tissue polypeptide antigen, and CEA seemed to perform the best, with a sensitivity and specificity of 71 and 76%, respectively. The combination of sialyl-Tn, CA 125, and tissue polypeptide antigen gave similar results and may be more cost-effective. However, one-fifth of the patients with early-stage cancer still showed up as false negatives even with use of the six markers in combination. Approaches other than serum assay alone will be needed to detect all malignant pelvic masses at an early stage.
对65例早期卵巢癌患者（45例I期和20例II期）和317例盆腔良性肿块患者检测了血清唾液酸化-Tn、唾液酸化-刘易斯Xi、CA 19-9、CA 125、癌胚抗原（CEA）和组织多肽抗原。作为单一检测方法，唾液酸化-Tn显示出最佳的敏感性和特异性，分别为46%和92%。CA 19-9检测出的癌症患者数量最多，但特异性最低。唾液酸化-Tn、CA 125、组织多肽抗原和CEA联合检测似乎效果最佳，敏感性和特异性分别为71%和76%。唾液酸化-Tn、CA 125和组织多肽抗原联合检测结果相似，且可能更具成本效益。然而，即使联合使用这六种标志物，仍有五分之一的早期癌症患者表现为假阴性。需要采用血清检测以外的其他方法来早期检测所有恶性盆腔肿块。
