Gibson A
Eur J Pharmacol. 1977 Jan 7;41(1):7-11. doi: 10.1016/0014-2999(77)90364-8.
The effect of testosterone and of castration on the contractility of the rat anococcygeus muscle, on plasma corticosterone concentrations, and on adrenal gland weights, was investigated. Castration was without effect on smooth muscle reactivity. However, testosterone increased muscle contractility to both NA and ACh, when given to control or castrated rats. Castration reduced both plasma corticosterone and adrenal gland weight, and this effect could be reversed by testosterone. It is concluded that changes in circulating testosterone levels cannot explain the lack of effect of adrenalectomy on muscle contractility. The possible mechanism of action of testosterone is discussed.
研究了睾酮和去势对大鼠肛尾肌收缩性、血浆皮质酮浓度及肾上腺重量的影响。去势对平滑肌反应性无影响。然而，给对照或去势大鼠注射睾酮后，可增强肌肉对去甲肾上腺素（NA）和乙酰胆碱（ACh）的收缩性。去势可降低血浆皮质酮水平和肾上腺重量，而睾酮可逆转这种作用。结论是循环睾酮水平的变化不能解释肾上腺切除术对肌肉收缩性无影响的原因。文中讨论了睾酮可能的作用机制。
