KORNGOLD L, VAN LEEUWEN G
J Exp Med. 1957 Oct 1;106(4):467-76. doi: 10.1084/jem.106.4.467.
Highly purified pathological macroglobulins, which had been characterized electrophoretically and in the ultracentrifuge, were studied by the Ouchterlony gel diffusion technique. These macroglobulins were shown to be antigenically related to normal gamma(1)-macroglobulin (19S) as well as the 7S gamma-globulins. The pathological macroglobulins differ among each other and they are antigenically deficient when compared with the normal macroglobulin. There is no correlation between the macroglobulin's antigenic structure and its physico-chemical properties.
通过奥克特洛尼凝胶扩散技术研究了经电泳和超速离心鉴定的高度纯化的病理性巨球蛋白。这些巨球蛋白显示出与正常γ(1)-巨球蛋白(19S)以及7Sγ球蛋白存在抗原相关性。病理性巨球蛋白彼此不同,与正常巨球蛋白相比,它们存在抗原缺陷。巨球蛋白的抗原结构与其物理化学性质之间没有相关性。