BAUER H, SHELDON W H
J Exp Med. 1957 Oct 1;106(4):501-8. doi: 10.1084/jem.106.4.501.
Mucormycosis was produced in rabbits with sustained, severe leukopenia and granulocytopenia induced by repeated injections of nitrogen mustard. Initially, these animals developed extensive fungus lesions at the site of inoculation which later became granulomatous and tended to heal. Only the early phases of host resistance appeared impaired by the virtual elimination of the polymorphonuclear leukocyte as a factor in the host response. Despite the persistent leukopenia and granulocytopenia, the later phases of host resistance resembled those of the normal animal. Thus, the behavior of the infection in this experiment differs greatly from the unchecked progression of mucormycosis in the metabolically abnormal animal with acute alloxan diabetes. The differences in the course of the disease and in the morphologic appearance of the lesions indicate that metabolic alterations in the host affect all phases of host resistance and not only the polymorphonuclear leukocytic response.
通过反复注射氮芥诱导家兔出现持续性严重白细胞减少和粒细胞减少，从而引发毛霉病。最初，这些动物在接种部位出现广泛的真菌病变，随后病变变成肉芽肿并趋于愈合。作为宿主反应的一个因素，多形核白细胞实际上被消除，似乎仅损害了宿主抵抗力的早期阶段。尽管白细胞减少和粒细胞减少持续存在，但宿主抵抗力的后期阶段与正常动物相似。因此，本实验中感染的表现与急性四氧嘧啶糖尿病代谢异常动物中毛霉病不受控制的进展有很大不同。疾病进程和病变形态外观的差异表明，宿主的代谢改变会影响宿主抵抗力的所有阶段，而不仅仅是多形核白细胞反应。
