Iwahashi M, Uozumi K, Ueda H, Shimotakahara S, Nakahara K, Hanada S, Arima T
Department of Internal Medicine, Minami Kyushuu Chuo National Hospital.
Rinsho Ketsueki. 1992 Jan;33(1):63-8.
A 64-year-old man was admitted to our hospital complaining of fever and edema in February, 1990. Lymph node biopsy revealed diffuse lymphoma pleomorphic type according to the LSG classification. On hematological examination, leukocyte count was 23,500/microliters, of which 36% abnormal lymphocytes expressing CD2, CD3, CD4 and CD25 as same as the lymph node cells. Anti-HTLV-I antibody in serum was positive. From these data, the diagnosis of adult T-cell leukemia (ATL) was made. ATL cells in the blood and lymph node expressed CD30 (Ki-1). CD30 positive ATL cells derived from the blood was increased after short-term culture. The induction of Ki-1 antigen in cell lines and short-term cultured cells from ATL patients was accompanied by the appearance of the HTLV-I related antigen. Then, we suggest that there was some relation between expression of the Ki-1 antigen and activation by HTLV-I in ATL cells.
1990年2月，一名64岁男性因发热和水肿入院。淋巴结活检根据LSG分类显示为弥漫性多形性淋巴瘤。血液学检查显示，白细胞计数为23,500/微升，其中36%的异常淋巴细胞表达CD2、CD3、CD4和CD25，与淋巴结细胞相同。血清中的抗HTLV-I抗体呈阳性。根据这些数据，诊断为成人T细胞白血病（ATL）。血液和淋巴结中的ATL细胞表达CD30（Ki-1）。短期培养后，血液中来源的CD30阳性ATL细胞增加。来自ATL患者的细胞系和短期培养细胞中Ki-1抗原的诱导伴随着HTLV-I相关抗原的出现。因此，我们认为Ki-1抗原的表达与ATL细胞中HTLV-I的激活之间存在某种关系。
