各种哺乳动物肾皮质切片对尿酸和对氨基马尿酸（PAH）的摄取。

Uptake of uric acid and p-aminohippurate (PAH) by renal cortical slices of various mammals.

Kim Y K, Jung J S, Lee S H

Department of Physiology, College of Medicine, Pusan National University, Korea.

Comp Biochem Physiol A Comp Physiol. 1992;101(1):53-8. doi: 10.1016/0300-9629(92)90627-3.

Abstract

Accumulation of uric acid and PAH was measured in renal cortical slices of various mammalian species. 2. The slice to medium ratio of uric acid was above unity in the rabbit, guinea pig, pig and cow, suggesting an active accumulation of uric acid, while it was near or below unity in the rat and mongrel dog. 3. Uric acid uptake in the rabbit, guinea pig and cow was significantly inhibited by PAH. 4. Uric acid was a potent inhibitor of PAH uptake in the rabbit, guinea pig, dog and pig, but much less potent in the rat and cow. 5. Kinetic analysis showed that uric acid inhibited PAH uptake in a competitive manner in all species studied except for the cow showing a noncompetitive type. 6. These results indicate that uric acid and PAH share a common transport mechanism at the basolateral membrane of the rabbit, guinea pig and pig.

摘要

在各种哺乳动物的肾皮质切片中测量尿酸和对氨基马尿酸（PAH）的蓄积情况。2. 兔、豚鼠、猪和牛的尿酸切片与培养基的比值高于1，表明尿酸有活跃的蓄积，而在大鼠和杂种狗中该比值接近或低于1。3. 兔、豚鼠和牛中尿酸的摄取受到PAH的显著抑制。4. 尿酸是兔、豚鼠、狗和猪中PAH摄取的强效抑制剂，但在大鼠和牛中效力要小得多。5. 动力学分析表明，除牛表现为非竞争性类型外，在所有研究的物种中尿酸均以竞争性方式抑制PAH摄取。6. 这些结果表明，在兔、豚鼠和猪的基底外侧膜上，尿酸和PAH共享一种共同的转运机制。