Sergent J, Signoret J L
Montreal Neurological Institute, McGill University, Canada.
Philos Trans R Soc Lond B Biol Sci. 1992 Jan 29;335(1273):55-61; discussion 61-2. doi: 10.1098/rstb.1992.0007.
Studies of brain-damaged patients have revealed the existence of a selective impairment of face processing, prosopagnosia, resulting from lesions at different loci in the occipital and temporal lobes. The lesions are often extensive, and it is unclear what functional aspects of face processing are normally served by the damaged areas, and whether they are uniquely devoted to the processing of faces. These issues are further addressed through a combined magnetic resonance imaging (MRI) and positron emission tomography (PET) study of regional cerebral blood flow (rCBF) in normal subjects performing different tasks of face and object processing. The results indicate different patterns of cerebral activation depending on the requirements of the tasks within the processing of faces, as well as a clear dissociation of the neural substrates underlying face and object processing. These results are compared with radiological data from prosopagnosic patients, and are put in relation with the patterns of deficits observed in the patients as a function of the location of their lesions. Together, the findings offer new evidence regarding the functional neuroanatomy of face and object processing.
对脑损伤患者的研究揭示了面部加工存在选择性损伤，即面孔失认症，它是由枕叶和颞叶不同部位的损伤引起的。这些损伤通常范围广泛，目前尚不清楚受损区域在正常情况下负责面部加工的哪些功能方面，以及它们是否专门用于面部加工。通过一项针对正常受试者进行不同面部和物体加工任务时的局部脑血流（rCBF）的磁共振成像（MRI）和正电子发射断层扫描（PET）联合研究，进一步探讨了这些问题。结果表明，根据面部加工任务的要求，大脑激活模式不同，同时面部和物体加工背后的神经基质也有明显分离。将这些结果与面孔失认症患者的放射学数据进行比较，并根据患者病变位置观察到的缺陷模式进行关联。这些发现共同为面部和物体加工的功能神经解剖学提供了新的证据。
