皮质酮处理大鼠中交感-肾上腺活动对营养状况的依赖性。

Dependence of the sympatho-adrenal activity on the nutritional status in corticosterone treated rats.

Davidović V, Vasilev I, Stojanović-Susulić V

Institute of Physiology and Biochemistry, Faculty of Sciences, University of Belgrade, Yugoslavia.

Comp Biochem Physiol Comp Physiol. 1992 Feb;101(2):309-12. doi: 10.1016/0300-9629(92)90537-z.

Abstract

An integrated sympatho-adrenal (SA) activity, expressed in terms of urinary catecholamines (CA) excretion, and direct sympathetic activity in the interscapular brown adipose tissue (IBAT), expressed in terms of noradrenaline (NA) turnover, were studied in corticosterone treated stock fed and sucrose overfed rats. 2. Corticosterone in stock fed rats significantly decreased both the rate of IBAT NA turnover and its mass as well as urinary NA excretion but did not change either IBAT NA content, urinary adrenaline excretion or adrenal CA content. 3. Sucrose overfeeding significantly increased SA activity, i.e. the rate of NA turnover in the IBAT and urinary excretion of CA. However, corticosterone did not inhibit the sucrose-induced sympathetic nervous system activation but potentiated the activity of adrenal medulla. 4. The results suggest that the effect of corticosterone treatment on the SA activity in rats is dependent, in addition to other factors, on the nutritional status of the animals.

摘要

以尿儿茶酚胺（CA）排泄量表示的交感 - 肾上腺（SA）综合活性，以及以去甲肾上腺素（NA）周转率表示的肩胛间棕色脂肪组织（IBAT）中的直接交感活性，在接受皮质酮处理的普通饲料喂养和蔗糖过量喂养的大鼠中进行了研究。2. 普通饲料喂养的大鼠体内的皮质酮显著降低了IBAT中NA的周转率及其质量以及尿中NA的排泄量，但未改变IBAT中NA的含量、尿中肾上腺素的排泄量或肾上腺CA的含量。3. 蔗糖过量喂养显著增加了SA活性，即IBAT中NA的周转率和CA的尿排泄量。然而，皮质酮并未抑制蔗糖诱导的交感神经系统激活，反而增强了肾上腺髓质的活性。4. 结果表明，除其他因素外，皮质酮处理对大鼠SA活性的影响还取决于动物的营养状况。