肩胛间棕色脂肪组织切除及蔗糖过量喂养对交感-肾上腺活动和代谢反应的影响。

Implications of interscapular brown adipose tissue removal and sucrose overfeeding on the sympatho-adrenal activity and metabolic responses.

Davidović V, Glisić S, Dedović N

Institute of Physiology and Biochemistry, Faculty of Sciences, University of Belgrade, Yugoslavia.

Comp Biochem Physiol A Comp Physiol. 1990;97(2):217-9. doi: 10.1016/0300-9629(90)90174-q.

Abstract

The influence of sucrose overfeeding on the sympatho-adrenal (SA) and metabolic responses was studied in sham-operated (SHAM) rats and in those with interscapular brown adipose tissue (IBAT) removed. 2. Sucrose feeding significantly increased the SA activity, mobilized the free fatty acids (FFA), but did not change glucose homeostasis in sham-operated rats. 3. IBAT removal in control rats fed a stock diet modified the SA activity whereas the levels of both blood glucose and serum FFA were unchanged. 4. However, sucrose in rats void of IBAT potentiated the activity of sympathetic nervous system only and prevented the FFA rise, which is seen in sham-operated sucrose fed rats indicating that the enhanced level of serum FFA in these animals principally originated from the IBAT.

摘要

在假手术（SHAM）大鼠以及肩胛间棕色脂肪组织（IBAT）被切除的大鼠中，研究了蔗糖过量喂养对交感 - 肾上腺（SA）和代谢反应的影响。2. 蔗糖喂养显著增加了SA活性，动员了游离脂肪酸（FFA），但在假手术大鼠中未改变葡萄糖稳态。3. 喂食普通饲料的对照大鼠切除IBAT后改变了SA活性，而血糖和血清FFA水平均未改变。4. 然而，在没有IBAT的大鼠中，蔗糖仅增强了交感神经系统的活性，并阻止了FFA升高，这在假手术蔗糖喂养的大鼠中可以看到，表明这些动物血清FFA水平的升高主要源于IBAT。