禁食大鼠的交感-肾上腺活动及代谢反应——肩胛间棕色脂肪组织的作用

Sympatho-adrenal activity and metabolic responses in fasted rats--the role of interscapular brown adipose tissue.

Davidović V, Dedović N, Glisić S

Institute of Physiology and Biochemistry, Faculty of Sciences, University of Belgrade, Yugoslavia.

Comp Biochem Physiol A Comp Physiol. 1988;91(4):697-700. doi: 10.1016/0300-9629(88)90952-8.

Abstract

Sympatho-adrenal (SA) and metabolic responses to fasting were studied in sham-operated (SHAM) rats and in those with interscapular brown adipose tissue (IBAT) removed. 2. Fasting significantly increased adrenaline (A) excretion and serum free fatty acids (FFA), but decreased noradrenaline (NA) excretion and blood glucose level in SHAM rats. 3. IBAT removal did not change metabolic responses while it markedly altered the SA activity. Fasting in animals void of IBAT potentiated the activity of adrenal medulla, inhibited the FFA rise and prevented glucose reduction, which is normally observed in SHAM-fasted rats. 4. Results suggest the significance of IBAT in the regulation of the blood level of energy substrates in fasted rats and in maintaining the basal level of NA excretion.

摘要

对假手术（SHAM）大鼠以及肩胛间棕色脂肪组织（IBAT）被切除的大鼠的交感 - 肾上腺（SA）和代谢对禁食的反应进行了研究。2. 禁食显著增加了假手术大鼠的肾上腺素（A）排泄和血清游离脂肪酸（FFA），但降低了去甲肾上腺素（NA）排泄和血糖水平。3. 切除IBAT并未改变代谢反应，但显著改变了SA活性。在没有IBAT的动物中禁食增强了肾上腺髓质的活性，抑制了FFA的升高并防止了血糖降低，而这在假手术禁食大鼠中通常会观察到。4. 结果表明IBAT在调节禁食大鼠能量底物的血液水平以及维持NA排泄的基础水平方面具有重要意义。