Nakazawa I, Yamagata S, Miura K
Tohoku J Exp Med. 1976;118 Suppl:149-58. doi: 10.1620/tjem.118.suppl_149.
In order to clarify the differences in lipid metabolism between malignant neoplastic and benign cases, livers of patients were biopsied under peritoneoscopy. One half of each sample was subjected to histologic examination and the other half to lipid analyses by means of thin layer chromatography and gas lipid chromatography. Histologic examination was necessary to confirm whether the lipid metabolism in the liver of patients would be influenced by hepatic disease or not. The most significant differences between malignant and benign cases were observed when the ratio of fatty acid content of the phospholipid fraction to that of triglyceride was calculated for each patient. These ratios were over 2.20 in 40 cases out of 47 malignant neoplastic cases without benign hepatic diseases and in 3 out of 4 malignant neoplastic cases combined with benign hepatic diseases, but were under 2.19 in 35 benign cases. Moreover, 4 cases of early gastric cancer and a case of relatively early pancreatic cancer included in the malignant cases mentioned above also showed the ratios over 3.00. This finding would be applicable for the clinical diagnosis of the malignant neoplastic diseases.
为了阐明恶性肿瘤病例与良性病例在脂质代谢方面的差异，在腹腔镜检查下对患者的肝脏进行活检。每个样本的一半进行组织学检查，另一半通过薄层色谱法和气相脂质色谱法进行脂质分析。组织学检查对于确认患者肝脏中的脂质代谢是否会受到肝脏疾病的影响是必要的。当计算每位患者磷脂部分脂肪酸含量与甘油三酯脂肪酸含量的比值时，观察到恶性病例与良性病例之间最显著的差异。在47例无良性肝脏疾病的恶性肿瘤病例中，有40例以及4例合并良性肝脏疾病的恶性肿瘤病例中有3例的这些比值超过2.20，而在35例良性病例中这些比值低于2.19。此外，上述恶性病例中包括的4例早期胃癌和1例相对早期的胰腺癌病例的比值也超过3.00。这一发现将适用于恶性肿瘤疾病的临床诊断。
