BUTTERWORTH K R, MANN M
Br J Pharmacol Chemother. 1957 Dec;12(4):422-6. doi: 10.1111/j.1476-5381.1957.tb00159.x.
The adrenal glands of atropinized cats were depleted of their content of adrenaline and noradrenaline by repeated intravenous doses of acetylcholine. In each experiment there was a similar percentage loss of both amines. This was irrespective of the degree of depletion, which ranged from 7.1% to 86.5%. In some experiments, adrenal blood was collected and it was found that the percentage of noradrenaline in the adrenal venous effluent (mean 62.0%) was similar to that in the amine lost from the depleted gland (mean 63.7%). In some experiments, the adrenaline and noradrenaline lost from the gland could be recovered quantitatively in the adrenal blood. The results indicate that, under these experimental conditions, synthesis is not taking place concurrently with the liberation of amines or that it is taking place so slowly as not to be detected.
通过反复静脉注射乙酰胆碱，使阿托品化猫的肾上腺中的肾上腺素和去甲肾上腺素含量耗尽。在每个实验中，两种胺类物质的损失百分比相似。这与耗尽程度无关，耗尽程度从7.1%到86.5%不等。在一些实验中，收集了肾上腺血液，发现肾上腺静脉流出液中去甲肾上腺素的百分比（平均62.0%）与从耗尽腺体中损失的胺类物质中的百分比（平均63.7%）相似。在一些实验中，从腺体中损失的肾上腺素和去甲肾上腺素可以在肾上腺血液中定量回收。结果表明，在这些实验条件下，胺类物质释放的同时合成并未发生，或者合成速度非常缓慢以至于无法检测到。
