乙基硫酯的抗结核活性，特别涉及二乙基二硫代间苯二甲酸酯。
The antituberculous activity of ethyl thiolesters with particular reference to diethyl dithiolisophthalate.
作者信息
DAVIES G E, DRIVER G W
出版信息
Br J Pharmacol Chemother. 1957 Dec;12(4):434-7. doi: 10.1111/j.1476-5381.1957.tb00161.x.
Abstract
Diethyl dithiolisophthalate exerts an antituberculous effect in mice comparable to that of isoniazid and streptomycin. It is effective when given in single doses, and against isoniazidresistant strains. It is most active when given subcutaneously either by injection or by absorption through the skin. Drug resistance has been demonstrated in mice, and isoniazid is active against such strains. The effects of this and other ethyl thiolesters are antagonized by their methyl analogues.
摘要
二硫代异酞酸二乙酯对小鼠的抗结核作用与异烟肼和链霉素相当。单剂量给药时有效，且对异烟肼耐药菌株有效。通过注射或经皮肤吸收皮下给药时活性最强。已在小鼠中证实有耐药性，而异烟肼对此类菌株有活性。该化合物及其他硫代乙酯的作用被其甲基类似物拮抗。
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