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1
The antagonism of the vascular effects of 5-hydroxytryptamine by BOL 148 and sodium salicylate in the human subject.BOL 148和水杨酸钠对人体5-羟色胺血管效应的拮抗作用。
Br J Pharmacol Chemother. 1957 Dec;12(4):498-503. doi: 10.1111/j.1476-5381.1957.tb00172.x.
2
Unsurmountable antagonism of brain 5-hydroxytryptamine2 receptors by (+)-lysergic acid diethylamide and bromo-lysergic acid diethylamide.（+）-麦角酸二乙酰胺和溴麦角酸二乙酰胺对脑5-羟色胺2受体具有不可克服的拮抗作用。
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The inhibition by sodium salicylate of oedema of the hind-paw of the rat induced by 5-hydroxytryptamine.水杨酸钠对5-羟色胺所致大鼠后爪水肿的抑制作用。
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[Protective action of lysergic acid ethylamide (LAE-32) on behavior changes & on histological lesions of the central nervous system induced in mice by chronic treatment with 5-hydroxytryptamine].[麦角酸乙酰胺（LAE - 32）对5 - 羟色胺慢性处理诱导的小鼠行为变化及中枢神经系统组织学损伤的保护作用]
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Mast cell amines and inosineinduced vasoconstriction in the rat hind limb.肥大细胞胺和次黄嘌呤诱导大鼠后肢血管收缩。
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2
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3
The effect of anti-inflammatory drugs on vascular smooth muscle.抗炎药物对血管平滑肌的作用。
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本文引用的文献

1
A method of assessing the mechanical properties of lungs and air-passages.一种评估肺和气道力学特性的方法。
Lancet. 1952 Jul 19;2(6725):109-11. doi: 10.1016/s0140-6736(52)92151-x.
2
Effect of cigarette-smoking on blood flow through the hand.吸烟对通过手部的血流的影响。
Br Med J. 1951 Oct 27;2(4738):1007-10. doi: 10.1136/bmj.2.4738.1007.
3
Hypertrophy of the seminal vesicle and prostate following degeneration of the tubules of the testis produced by various methods.
J Physiol. 1957 Jun 18;137(1):16-7P.
4
Effects of d-lysergic acid diethylamide and its brom derivative on cardiovascular responses to serotonin and on arterial pressure.d-麦角酸二乙酰胺及其溴衍生物对心血管系统对血清素反应及动脉血压的影响。
J Pharmacol Exp Ther. 1957 Feb;119(2):240-7.
5
The inhibition by sodium salicylate of oedema of the hind-paw of the rat induced by 5-hydroxytryptamine.水杨酸钠对5-羟色胺所致大鼠后爪水肿的抑制作用。
Br J Pharmacol Chemother. 1957 Mar;12(1):28-9. doi: 10.1111/j.1476-5381.1957.tb01357.x.
6
The action of 5-hydroxytryptamine on the blood vessels of the human hand and forearm.5-羟色胺对人手部和前臂血管的作用。
Br J Pharmacol Chemother. 1955 Dec;10(4):445-50. doi: 10.1111/j.1476-5381.1955.tb00102.x.
7
Humoral effects of metastasising carcinoid tumours.转移性类癌肿瘤的体液效应。
Lancet. 1955 Nov 12;269(6898):1004-9. doi: 10.1016/s0140-6736(55)93431-0.
8
Reactions of the blood vessels of the human forearm to increases in transmural pressure.人体前臂血管对跨壁压力升高的反应。
J Physiol. 1954 Sep 28;125(3):508-24. doi: 10.1113/jphysiol.1954.sp005177.
9
Drugs which antagonize 5-hydroxytryptamine.拮抗5-羟色胺的药物。
Br J Pharmacol Chemother. 1954 Jun;9(2):240-8. doi: 10.1111/j.1476-5381.1954.tb00848.x.
10
Salicylates and the plasma level of adrenal steroids.
Lancet. 1954 May 15;266(6820):1010-1. doi: 10.1016/s0140-6736(54)92401-0.

BOL 148和水杨酸钠对人体5-羟色胺血管效应的拮抗作用。

The antagonism of the vascular effects of 5-hydroxytryptamine by BOL 148 and sodium salicylate in the human subject.

作者信息

GLOVER W E, MARSHALL R J, WHELAN R F

出版信息

Br J Pharmacol Chemother. 1957 Dec;12(4):498-503. doi: 10.1111/j.1476-5381.1957.tb00172.x.

DOI:10.1111/j.1476-5381.1957.tb00172.x
PMID:13489181
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1510595/
Abstract

2-Bromo-(+)-lysergic acid diethylamide (BOL 148) is a specific antagonist of the constrictor response of the forearm and hand blood vessels to intra-arterial infusions of 5-hydroxytryptamine. This has been shown to be a direct action in the tissue concerned, since the antagonism was as effective when the drug was given by local arterial injection as when given intravenously. Sodium salicylate is also a specific antagonist of 5-hydroxytryptamine, but its action is indirect, occurring only when the general serum level was raised above 10 or 20 mg.%; local limb concentrations of 30 to 40 mg.% had no antagonistic effect. The mechanism of the antagonistic effect of salicylate is not known. It is not related to the associated hyperventilation but is possibly due to the secondary release of, or synergism with, some other substance, probably a hormone.

摘要

2-溴-(+)-麦角酸二乙酰胺（BOL 148）是前臂和手部血管对动脉内注入5-羟色胺产生收缩反应的特异性拮抗剂。这已被证明是在相关组织中的直接作用，因为当通过局部动脉注射给药时，该拮抗剂的效果与静脉给药时一样有效。水杨酸钠也是5-羟色胺的特异性拮抗剂，但其作用是间接的，仅在血清总水平升高至10或20mg.%以上时才会出现；局部肢体浓度为30至40mg.%时没有拮抗作用。水杨酸盐拮抗作用的机制尚不清楚。它与相关的过度通气无关，但可能是由于某些其他物质（可能是一种激素）的继发性释放或协同作用。